Publications and News
Since 2014, our research team has made major breakthroughs in HIV research, moving closer to a cure each year.
Publications and News of Interest
Structural rearrangements in the nucleus localize latent HIV proviruses to a perinucleolar compartment supportive of reactivation
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Excision BioTherapeutics Receives FDA Fast Track Designation for EBT-101, a First-in-Class CRISPR-Based Gene Therapy Candidate to Functionally Cure HIV-1
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Strategic self-limiting production of infectious HIV particles by CRISPR in permissive cells
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Hong Liu, Chen Chen, Shuren Liao, Danielle K. Sohaii, Conrad R.Y. Cruz, Tricia H. Burdo, Thomas J. Cradick, Anand Mehta, Carlos Barrero, Magda Florez, Jennifer Gordon, Stephane Grauzam, James Dressman, Shohreh Amini, Catherine M. Bollard, Rafal Kaminski, Kamel Khalili
CRISPR editing of CCR5 and HIV-1 facilitates viral elimination in antiretroviral drug-suppressed virus-infected humanized mice
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Prasanta K Dash, Chen Chen, Rafal Kaminski, Hang Su, Pietro Mancuso, Brady Sillman, Chen Zhang, Shuren Liao, Sruthi Sravanam, Hong Liu, Emiko Waight, Lili Guo, Saumi Mathews, Rahsan Sariyer, R Lee Mosley, Larisa Y Poluektova, Maurizio Caocci, Shohreh Amini, Santhi Gorantla, Tricia H Burdo, Benson Edagwa, Howard E Gendelman, Kamel Khalili
Human NK Cells Confer Protection Against HIV-1 Infection in Humanized Mice
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Can M. Sungur, Qiankun Wang, Ayşe N. Ozantürk, Hongbo Gao, Aaron J. Schmitz, Marina Cella, Wayne M. Yokoyama,and Liang Shan.
Safety and Virologic Impact of the IL-15 Superagonist N-803 in People Living with HIV: A Phase 1 Trial
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Jeffrey S. Miller, Zachary B. Davis, Erika Helgeson, Cavan Reilly, Ann Thorkelson, Jodi Anderson, Noemia S. Lima, Siri Jorstad, Geoffrey T. Hart, John H. Lee, Jeffrey T. Safrit, Hing Wong, Sarah Cooley, Lavina Gharu, Hyunsoo Chung, Patrick Soon-Shiong, Curtis Dobrowolski, Courtney V. Fletcher, Jonathan Karn, Daniel C. Douek & Timothy W. Schacker.
Latency Reversal Plus Natural Killer Cells Diminish HIV Reservoir in vivo
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Jocelyn T. Kim, Tian-Hao Zhang, Camille Carmona, Bryanna Lee, Christopher S. Seet, Matthew Kostelny, Nisarg Shah, Hongying Chen, Kylie Farrell, Mohamed S. A. Soliman, Melanie Dimapasoc, Michelle Sinani, Kenia Yazmin Reyna Blanco, David Bojorquez, Hong Jiang, Yuan Shi, Yushen Du, Natalia L. Komarova, Dominik Wodarz, Paul A. Wender, Matthew D. Marsden, Ren Sun & Jerome A. Zack
CRISPR Based Editing of SIV Proviral DNA in ART Treated Non-Human Primates
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Pietro Mancuso, Chen Chen, Rafal Kaminski, Jennifer Gordon, Shuren Liao, Jake A. Robinson, Mandy D. Smith, Hong Liu, Ilker K. Sariyer, Rahsan Sariyer, Tiffany A. Peterson, Martina Donadoni, Jaclyn B. Williams, Summer Siddiqui, Bruce A. Bunnell, Binhua Ling, Andrew G. MacLean, Tricia H. Burdo & Kamel Khalili
Sequential LASER ART and CRISPR Treatments Eliminate HIV-1 in a Subset of Infected Humanized Mice
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Prasanta K. Dash, Rafal Kaminski, Ramona Bella, Hang Su, Saumi Mathews, Taha M. Ahooyi, Chen Chen, Pietro Mancuso, Rahsan Sariyer, Pasquale Ferrante, Martina Donadoni, Jake A. Robinson, Brady Sillman, Zhiyi Lin, James R. Hilaire, Mary Banoub, Monalisha Elango, Nagsen Gautam, R. Lee Mosley, Larisa Y. Poluektova, JoEllyn McMillan, Aditya N. Bade, Santhi Gorantla, Ilker K. Sariyer, Tricia H. Burdo, Won-Bin Young, Shohreh Amini, Jennifer Gordon, Jeffrey M. Jacobson, Benson Edagwa, Kamel Khalili & Howard E. Gendelman.
Excision of HIV-1 DNA by Gene Editing: A Proof-of-Concept in vivo Study
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Rafal Kaminski, Ramona Bella, Chaoran Yin, Jessica Otte, Pasquale Ferrante, Howard E. Gendelman, Hailong Li, Rosemarie Booze, Jennifer Gordon, Wenhui Hu & Kamel Khalili.
